The core mission of the Research Center for Biomass Zero-carbon Fuels is to revolutionize energy production by utilizing discarded biomass to generate high-value-added fuels. This initiative is poised to drive a significant shift in China’s raw materials system, transitioning from reliance on fossil fuels buried beneath the earth to harnessing renewable energies available on the earth’s surface. Besides, the center plays a supportive role in building a resource carbon neutrality mode in energy, chemical industry, transportation, steel, among other industries. To conquer a technological difficulty in preparing high-value fuels with discarded biomass through engineering methods, the center aims to unblock a complete innovation chain, spanning from basic research to industrialization. Meanwhile, its researches focus on three major directions, including producing high-value fuel oils with biomass, producing hydrogen with biomass/wastes, and preparing alcohol with biomass. Ultimately, it is expected to establish a set of technology and engineering equipment for preparing high-value fuels with biomass efficiently.